The cellular phenotypes are regulated with the signaling pathways consist of molecular interactions. Network of several signaling pathways activates the stem cells and cancer to transit the cellular phonotypes. The molecules in the signaling pathway are epigenetically regulated upon the stimulation, which leads to dynamic changes in cell types such as differentiation of stem cells or malignancy of cancer cells. Considering that the disease status is involved in signaling pathway alteration, the investigation in epigenetic changes to find the targets of therapeutics are clinically of importance.
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