Abstract

Recent Advancement in Methodology for Understanding Epigenetic Modifications

Epigenetics play a significant role in the regulation of various important cellular processes, and dysregulation at the epigenetic level might be a cause of serious pathologies, such as cancer, neurodevelopmental disorders, neurodegeneration, and intellectual disability. In spite of substantial technological advances for epigenetic profiling, there is still a need for a systematic understanding of how epigenetics regulates cellular machinery, and disease pathogenesis. The development of precise tools, techniques and computational methods for investigating complex epigenetic profiles is essential for unravelling the mechanisms underlying cellular development, and the intricate interaction networks determining and identifying DNA methylation, RNA methylation, and chromatin modifications and to control gene expression. In this chapter, we examine the recent advances in the field of “epigenetics” including tools for processing diverse types of epigenetic data, and study the expression of genes and protein dynamics.


Author(s):

Shashikant Tiwari



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