Thyroid cancer is the most common endocrine cancer in the word and its incidence is on the rise. Though generally associated with a very good prognosis, few cases may demonstrate resistance to treatment such as radio-iodine therapy. lncRNAs have shown to be involved in several steps of thyroid carcinogenesis. It can act as a prognostic and diagnostic marker. Altered levels of specific lncRNAs have also shown to be associated with resistance to radioiodine treatment. Therapy with lncRNA has also shown to return radio-sensitivity in thyroid cancer cell lines.