Journal of Clinical Epigenetics is an open access, companion assessed journal that includes all parts of epigenetic standards and instruments in connection to human illness, conclusion and treatment. Clinical trials and research in illness model living beings are especially welcome.
This journal is isolated into the accompanying segments: Aging, improvement, engraving and conceptive epigenetics, allergy, immunology, pathogens and irritation, cancer epigenetics and diagnostics, cardiovascular epigenetics, endocrinology and metabolic illness, epigenetic treatment and clinical trials, innovative epigenetics treatments, neurology and psychiatry, nutritional and ecological epigenetics.
Open access is an innovative publishing platform in which all articles published in this journal will be accessible online, to anyone, anywhere in the world, completely free of charge. Articles once submitted to the journal are peer-reviewed wisely. Once accepted, articles are then proof-read for publication.
This scholarly publishing includes a wide range of fields in epigenetics discipline to create a platform for the authors to make their contribution towards the journal and the editorial tracking system ensures a peer review process for the submitted manuscripts for quality. Reviewers can download manuscripts and submit their valuable opinions to the editor. Editors can manage the whole submission/review/revise/publishing process.
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It is a study of the nutritional conditions or factors which affects the DNA indirectly by modifying epigenetic factors.
Nutrients can reverse or change epigenetic phenomena such as DNA methylation and histone modifications, thereby modifying the expression of critical genes associated with physiologic and pathologic processes, including embryonic development, aging, and carcinogenesis.It appears that nutrients and bioactive food components can influence epigenetic phenomena either by directly inhibiting enzymes that catalyze DNA methylation or histone modifications or by altering the availability of substrates necessary for those enzymatic reactions.
In this regard, nutritional epigenetics has been viewed as an attractive tool to prevent pediatric developmental diseases and cancer as well as to delay aging-associated processes. In recent years, epigenetics has become an emerging issue in a broad range of diseases such as type 2 diabetes mellitus, obesity, inflammation, and neurocognitive disorders.
Related Journals of Nutritional Epigenetics
International Publisher of Science, Technology and Medicine, Journal of Nutritional Disorders & Therapy, Vitamins & Minerals, Journal of Medical Epigenetics, Journal of Clinical Epigenetics, Journal of Advanced Nutrition and Human Metabolism, European Journal of Clinical Nutrition, Journal of Nutrients.
Epigenetic Therapy and Clinical trials is the use of drugs or other epigenome-influencing techniques to treat medical conditions in clinical trials. Many diseases, including cancer, heart disease, diabetes and mental illnesses are influenced by epigenetic mechanisms.
Related Journals of Epigenetic Therapy and Clinical trials
Journal of Clinical Trials, Journal of Cancer Clinical Trials, Journal of Reviews on Recent Clinical Trials and Journal of Clinical Epigenetics.
An epigenome consists of a record of the chemical changes to the DNA and histone proteins of an organism; these changes can be passed down to an organism′s offspring. Changes to the epigenome can result in changes to the structure of chromatin and changes to the function of the genome.
Related Journals of Epigenome
Epigenomics Journal, Journal of Genetics & Epigenetics, Epigenetics & Chromatin and Epigenetics Journal.
It is a study of the molecular mechanisms of environmental factors interacting with the epigenome and impacting the biology in specific organ and tissue and cells, resulted in adaptive evolutionary changes or disease development.
Related Journals of Environmental Epigenetics
Journal of Petroleum & Environmental Engineering, Journal of Geography & Natural Disasters, Journal of Environmental & Analytical Toxicology, Journal of Environmental Analytical Chemistry, Journal of Environmental Epigenetics, Environmental and Molecular Mutagenesis Journal, International Journal of Hygiene and Environmental Health, Journal of Environmental Health, Journal of Environmental Sciences, International Journal of Environmental Health Research, Environmental and Molecular Mutagenesis.
Epigenetic phenomena are defined as heritable mechanisms that establish and maintain mitotically stable patterns of gene expression without modifying the base sequence of DNA. The major epigenetic features of mammalian cells include DNA methylation, post-translational histone modifications and RNA-based mechanisms including those controlled by small non-coding RNAs (miRNAs).
The term cardiovascular epigenetics refers to heritable changes in cardiac gene expression (active versus inactive genes) that does not involve changes to the underlying DNA sequence, a change in phenotype without a change in genotype. The impact of epigenetic mechanisms in cardiovascular pathophysiology is now emerging as a major player in the interface between genotype to phenotype variability.
An important aspect of epigenetic mechanisms is that they are potentially reversible and may be influenced by nutritional-environmental factors and through gene–environment interactions, all of which have an important role in complex, multifactorial diseases such as those affecting the cardiovascular system. Gene expression regulation through the interplay of DNA methylation and histone modifications is well-established, although the knowledge about the function of epigenetic signatures in cardiovascular disease is still largely unexplored
Related Journals of Cardiovascular Epigenetics
Journal of Clinical & Experimental Cardiology, Cardiovascular Pharmacology: Open Access, Cardiovascular Pathology: Open Access, International Journal of Cardiovascular Research, Cardiovascular Genetics, Journal of the American College of Cardiology, European Heart Journal, Cardiovascular Interventions, Journal of Heart and Lung Transplantation, Journal of the American Society of Echocardiography, Cardiovascular Research, Basic Research in Cardiology, Journal of Vascular Surgery, Journal of the American Heart Association, Circulation Journal, Heart Failure Reviews and Journal of Clinical Epigenetics
Epigenetic changes in cancer cells not only provide novel targets for drug therapy but also offer unique prospects for cancer diagnostics. The three main approaches to assess the epigenetic state of individual gene loci are to (1) measure gene expression, (2) determine histone modifications and chromatin protein composition and (3) analyze promoter DNA methylation status. Chromatin immunoprecipitation has been an extremely useful research tool to analyze chromatin protein composition and modifications.
However, it has not advanced sufficiently yet to become a clinically useful diagnostic method, in contrast to serum proteomics by mass spectrometry, which is progressing rapidly in clinical feasibility studies. Gene expression microarray analysis has proved to be a powerful method for identifying novel subclasses of cancer and predicting clinical outcome or response to therapy. However, gene expression analysis is generally not viewed as epigenetic analysis, in part because mechanistic understanding of gene regulation evolved from studies of transcriptional control by transcription factors, which does not necessarily involve mitotically stable epigenetic change, although the fields of gene regulation and epigenetics are moving closer.
The major interest in cancer epigenetics as a diagnostic tool is in localized epigenetic silencing. The use of gene expression microarray studies to identify non-transcribed genes as candidates for promoter CpG island hypermethylation has had limited success, because lack of gene expression can stem from other causes aside from epigenetic silencing. For the most part, cancer epigenetics has relied on measurements of CpG island DNA hypermethylation.
DNA methylation markers are used in cancer diagnostics for both disease classification and disease detection. As a classification tool, CpG island hypermethylation is generally analyzed on sufficient quantities of primary tissue such as a surgically resected tumor sample.
The DNA methylation status of individual gene promoters can be used for general prognosis or to predict response to a particular therapy. There have been numerous reports describing an association between hypermethylation of individual genes and overall clinical outcome (prognosis) for various types of cancer. Individual methylation markers have also been linked to breast cancer metastasis.
In particular, methylation of the E-cadherin (CDH1) promoter appears to be required for invasion and metastasis. It is more difficult to make a convincing case that a DNA methylation marker is a predictor of response to a specific therapy, and not just a general prognostic marker of clinical outcome, independent of therapy.
One of the best cases has been made for hypermethylation of the O6-methylguanine methyltransferase (MGMT) promoter, which is associated with increased survival in glioma patients treated with alkylating agents. Melanoma cells with acquired resistance to the antineoplastic alkylating compound fotemustine, by repeated in vitro drug exposure, were shown to have reactivated the MGMT gene.
Related Journals of Cancer Epigenetics and Diagnostics
Journal of Cancer Biomarkers, Journal of Cancer Diagnosis, Cancer Medicine & Anti Cancer Drugs, Journal of Lung Cancer Diagnosis & Treatment, Journal of Cancer Epigenetics, Cancer Discovery, Cancer, European Journal of Cancer, Molecular Cancer, Cancer Letters and Cancer Immunology and Immunotherapy.
The Epigenetics of Allergy main focus on DNA methylation and histone modifications, their relevance in the process of allergic sensitization, their impact on disease heritability and association with environmental exposure and allergy phenotype.
Related Journals of Epigenetics of Allergy
Journal of Allergy & Therapy, Journal of Pigmentary Disorders, Journal of Clinical & Cellular Immunology, Journal of Allergy and Clinical Immunology, Allergy, Journal of Asthma & Clinical Immunology.
The imprinting epigenetics are defined by the inheritance of epigenetic tags from cell generation to cell generation and from the parents to their offspring.
The epigenetic tags on imprinted genes usually stay put for the life of the organism. But they are reset during egg and sperm formation. Regardless of whether they came from mom or dad, certain genes are always silenced in the egg, and others are always silenced in the sperm
Related Journals of Imprinting Epigenetics
Journal of Clinical Epigenetics.
Epigenetics refers to covalent modifications of DNA and core histones that regulate gene activity without altering DNA sequence. To date, the best-characterized DNA modification associated with the modulation of gene activity is methylation of cytosine residues within CpG dinucleotides.
Human disorders associated with epigenetic abnormalities include rare imprinting diseases, molar pregnancies, and childhood cancers. Germ cell development and early embryo development are critical times when epigenetic patterns are initiated or maintained. It is a type of epigenetic condition, heritable change occurs in Germ cell development and early embryo development.
Related Journals of Reproductive Epigenetics
Journal of Fertilization: In Vitro - IVF-Worldwide, Reproductive Medicine, Genetics & Stem Cell Biology, Reproductive System & Sexual Disorders, Gynecology & Obstetrics, Journal of Reproduction, Journal of Human Reproduction, Asian Pacific Journal of Reproduction, Journal of Biology of Reproduction, Journal of Reproductive Biology and Endocrinology, International Journal of Reproduction, Contraception, Obstetrics and Gynecolog, Journal of Reproductive BioMedicine Online, Journal of Reproduction Fertility and Development.
Aging is associated with a wide range of human disorders, including cancer, diabetes, cardiovascular, and neurodegenerative diseases. Aging is associated with profound epigenetic changes, resulting in alterations of gene expression and disturbances in broad genome architecture and the epigenomic landscape.
The potential reversibility of these epigenetic changes that occur as a hallmark of aging offers exciting opportunities to alter the trajectory of age-related diseases.
Related Journals of Aging Epigenetics
Journal of Aging Science, Journal of Aging Studies, Journal of Aging and Health, Journal on Aging Research, Psychology and Aging, Frontiers in Aging Neuroscience, Current Aging Science.
Asthma is caused by both heritable and environmental factors. The study of epigenetics of asthma plays an important role in understanding and possible treatment of epigenetical asthma.
Related Journals of Epigenetics of Asthma
Journal of Pulmonary & Respiratory Medicine, Journal of Ancient Diseases & Preventive Remedies, Journal of Asthma & Clinical Immunology, Journal of Asthma, Journal of Asthma and Allergy and Allergy and Asthma Proceedings.
Epigenetic abnormalities associated with metabolic disorders like obesity, hypothyroidism, hyperthyroidism, diabetes, dyslipidaemia etc.,
Related Journals of Epigenetics of Metabolic Disorders
Metabolomics: Open Access, Journal of Diabetes & Metabolism, Journal of Metabolic Syndrome, Journal of Clinical Epigenetics, Journal of Diabetes & Metabolic Disorders, Journal of Inherited Metabolic Disease, Journal of Clinical Endocrinology and Metabolism, Reviews in Endocrine and Metabolic Disorders and Journal of Endocrinology.
Epigenetic therapy is the use of drugs or other epigenome-influencing techniques to treat medical conditions. Many diseases, including cancer, heart disease, diabetes, and mental illnesses are influenced by epigenetic mechanisms, and epigenetic therapy offers a potential way to influence those pathways directly.
Related Journals of Epigenetic Therapy
Hereditary Genetics: Current Research, Cellular and Molecular Biology, Human Molecular Genetics, Genetics in Medicine, Journal of Medical Genetics, Circulation: Cardiovascular Genetics, Genetic Epidemiology, European Journal of Human Genetics,Current Protocols in Human Genetics, Pharmacogenetics and Genomics, Twin Research and Human Genetics, Journal of Human Genetics, Human gene therapy methods and BMC Genetics.
Transgenerational Epigenetics gives an exhaustive investigation of the legacy of epigenetic phenomena between generations. This epigenetic data can be exchanged through various components including DNA methylation, histone changes or RNA and the impacts can endure for different generations.
Related Journal of Transgeneration Epigenetics
Cloning & Transgenesis, Human Molecular Genetics, Genetics in Medicine, Journal of Medical Genetics and Journal of Clinical Epigenetics.
Cigarette smoking leads to some of the most preventable causes of death and illness in the world. Cigarette use is associated with a range of deleterious genetic changes.
The findings shed new light on the biological processes whereby smoking increases the risk of a variety of diseases and adverse health outcomes.
Besides damaging lungs, cigarettes can also wreak havoc on genes that control immune responses, sperm quality, and the risk of developing certain diseases.
Related Journals of Cigarette Smoking and Epigenetics
Journal of Addiction Research & Therapy, Epidemiology: Open Access, American Journal of Medical Genetics, Journal of Epigenetics and Human Molecular Genetics.
Epigenetic dysregulation is now a hallmark of several complex pathologies, including cancer, metabolic disorders, cardiovascular and neurological diseases.
Disease-specific epigenetic signatures such as DNA methylation, hydroxymethylation, and non-coding RNAs are now being utilized clinically for prognostics and diagnostics, while an expanding collection of genetically aberrant, abnormally expressed or chromatin-interacting epigenetic enzymes are positioned as promising targets for therapeutic intervention.
Related Journals of Impact of Epigenetics on Precision Treatment and Medicine
Translational Medicine, Journal of Forensic Research, Emergency Medicine: Open Access, European Journal of Human Genetics, American Journal of Medical Genetics, Journal of Medical Genetics, Journal of Cancer Epigenetics, Human Molecular Genetics, Genetics in Medicine, Journal of Medical Genetics, Circulation: Cardiovascular Genetics, Genetic Epidemiology, European Journal of Human Genetics,Current Protocols in Human Genetics, Pharmacogenetics and Genomics, Twin Research and Human Genetics, Journal of Human Genetics, Human gene therapy methods and BMC Genetics.
Author(s): Marcelo Alberto Oliva
Author(s): David Penny