Overexpression of Histone deacetylases as key players in mediating gene expression have been demonstrated to be involved in numerous types of cancer and some isoforms also in neurological, inflammatory and viral pathologies. There is large evidence that histone deacetylase inhibitors can be applied for their treatment. This review summarizes recent clinical aspects and efforts in the drug development of histone deacetylase inhibitors and their potential use in therapy.
Not only novel potent and selective histone deacetylase inhibitors to fight specific types of cancer or non-cancerous diseases are presented but also the interesting therapeutic approach to use histone deacetylase inhibitors joint with other epigenetic modulators and / or other chemotherapeutics to combine their therapeutic potential are being discussed.
Clemens Zwergel, Giulia Stazi, Sergio Valente and Antonello Mai