Reach Us +44-1235425476
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Histone Deacetylase Inhibitors: Updated Studies in Various Epigenetic-Related Diseases

Overexpression of Histone deacetylases as key players in mediating gene expression have been demonstrated to be involved in numerous types of cancer and some isoforms also in neurological, inflammatory and viral pathologies. There is large evidence that histone deacetylase inhibitors can be applied for their treatment. This review summarizes recent clinical aspects and efforts in the drug development of histone deacetylase inhibitors and their potential use in therapy.

Not only novel potent and selective histone deacetylase inhibitors to fight specific types of cancer or non-cancerous diseases are presented but also the interesting therapeutic approach to use histone deacetylase inhibitors joint with other epigenetic modulators and / or other chemotherapeutics to combine their therapeutic potential are being discussed.


Author(s):

Clemens Zwergel, Giulia Stazi, Sergio Valente and Antonello Mai



Abstract | Full-Text | PDF

Share this  Facebook  Twitter  LinkedIn  Google+
Flyer image

Abstracted/Indexed in

  • Google Scholar
  • China National Knowledge Infrastructure (CNKI)
  • Directory of Research Journal Indexing (DRJI)
  • WorldCat
  • Publons
  • Geneva Foundation for Medical Education and Research
  • Secret Search Engine Labs